Administer hydrocortisone, 5 mg per kg, or approximately 250 mg intravenously (prednisone, 20 mg orally, in mild cases). The reason is to reduce the risk of recurrent or prolonged anaphylaxis. These doses may be repeated every six hours, as needed. Most patients treated with antihistamines and steroids have complete remission after the gradual decline in steroids.
Hapten formation through the steroid glyoxal, which is a cortisol degradation product whose aqueous solution could also be responsible for the carbon rings of steroids in the body's immune system.