The use of steroids, such as prednisolone, for certain rheumatic conditions may increase the risk of viral and bacterial infections. Corticosteroids have a wide variety of effects on the immune system, and the dosage of the drug has a great impact on the risk of infection. High doses (e.g. 60 mg of prednisone) can double the risk of serious infection, even at doses as low as 10-20 mg.
However, the risk of infection with corticosteroid doses lower than 10 mg is unclear. Corticosteroids can also be used to replace certain hormones that the body doesn't produce naturally, for example, in people with Addison's disease. Steroids reduce the activity of the immune system, which is the body's natural defense against diseases and infections. For most people, steroid inhalers and steroid injections shouldn't cause annoying side effects.
High-dose inhaled steroids can sometimes cause some of the more serious side effects that are most commonly related to steroid tablets, but this is rare. When using steroids, it is important to be aware of the potential side effects and take steps to control their impact. People with ongoing infections, such as tuberculosis (TB), should use steroid inhalers or sprays with caution. It is also important to talk to your doctor about any concerns you may have about using steroids.
